Definition of Great saphenous veinGreat saphenous vein: The larger of the two saphenous veins, the principal veins that run up the leg near the surface. The great saphenous vein goes from the foot all the way up to the saphenous opening, an oval aperture in the broad fascia of the thigh. The vein then passes through this fibrous membrane. Also known as large saphenous vein. Last Editorial Review: 3/19/2012
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