Definition of Heart septumHeart septum: The dividing wall between the right and left sides of the heart. That portion of the septum that separates the right and left atria of the heart is termed the atrial, or interatrial, septum, whereas the portion of the septum that lies between the right and left ventricles of the heart is called the ventricular, or interventricular, septum. Last Editorial Review: 3/19/2012
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