Definition of Piriformis syndromePiriformis syndrome: Irritation of the sciatic nerve that is caused by compression of the nerve within the buttock by the piriformis muscle. Typically, the pain of piriformis syndrome is increased by contraction of the piriformis muscle, prolonged sitting, or direct pressure applied to the muscle. Buttock pain is common. Piriformis syndrome can cause difficulty walking due to pain in the buttock and lower extremity. Piriformis syndrome is one of the causes of sciatica. Piriformis Last Editorial Review: 3/19/2012
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