Definition of Stroke volumeStroke volume: The amount of blood pumped by the left ventricle of the heart in one contraction. The stroke volume is not all the blood contained in the left ventricle; normally, only about two-thirds of the blood in the ventricle is expelled with each beat. Together with the heart rate, the stroke volume determines the output of blood by the heart per minute (cardiac output). Last Editorial Review: 3/19/2012
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