Definition of SpondylolysisSpondylolysis: The breaking down (dissolution) of a portion of a vertebra. The affected portion of the vertebra is a bone segment called the pars interarticularis, which can separate. Spondylolysis can be a cause of abnormal movement of the spine (spondylolisthesis) and lead to localized back pain. Last Editorial Review: 3/19/2012
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