Definition of Erythropoietin (EPO)
Erythropoietin (EPO): A hormone produced by the
kidney that promotes the formation of red blood cells in the
bone marrow. EPO is a glycoprotein (a protein with a
sugar attached to it). Human EPO has a molecular weight of 34,000.
The kidney cells that make EPO are specialized and are
sensitive to low oxygen levels in the blood. These cells release EPO when the oxygen level is low in the kidney. EPO then stimulates the bone marrow to produce more red cells and thereby increase the oxygen-carrying capacity of the blood.
EPO is the prime regulator of red blood cell production. Its major
functions are to promote the differentiation and development of red
blood cells and to initiate the production of hemoglobin, the
molecule within red cells that transports oxygen.
The EPO gene has been found on human chromosome 7 (in band 7q21). EPO is produced not only in the kidney but also, to a lesser extent, in the liver. Different DNA sequences flanking the EPO gene act to control kidney versus liver production of EPO.
The measurement of EPO in the blood is useful in the study of bone marrow disorders and kidney disease. Normal levels of EPO are 0 to 19 mU/ml
(milliunits per milliliter). Elevated levels of EPO can be seen in
polycythemia, a disorder in which there is an excess of red
blood cells. Lower than normal levels of EPO are seen in chronic
renal failure.
Using recombinant DNA technology, EPO has been
synthetically produced for use in persons with certain types of
anemia -- such as anemia due to kidney failure, anemia secondary to AZT treatment of AIDS , and anemia associated with cancer.
EPO has been much misused as a performance-enhancing drug in
endurance athletes including some cyclists (in the Tour de
France), long-distance runners, speed skaters, and Nordic (cross-country) skiers. When misused in such situations, EPO is thought to be especially dangerous (perhaps because dehydration can further increase the
viscosity of the blood, increasing the risk for heart attacks and
strokes. EPO has been banned by the Tour de France, the Olympics, and other sports organizations.
For more information, see Erythropoietin (EPO).
Last Editorial Review: 2/12/2001
- epoetin alfa, Epogen, Procrit - Explains the medication epoetin alfa (Epogen, Procrit), a drug used to treat anemia (low red blood cell count) that is associated with chronic kidney failure in patients who are or will be receiving renal dialysis.
- Hemoglobin - Read about hemoglobin - the protein molecule in red blood cells. Learn what normal, low, and high level hemoglobin counts mean on MedicineNet.com
- Kidney Failure - Learn about kidney failure, in which the body has fluid retention, risen blood pressure, toxin build up and lack of red blood cells. Symptoms include fatigue, nausea, and apetite loss.
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