Definition of LDL (low-density lipoprotein)LDL (low-density lipoprotein): A molecule that is a combination of lipid (fat) and protein. Lipoproteins are the form in which lipids are transported in the blood. Low-density lipoprotein (LDL) transports cholesterol from the liver to the tissues of the body. LDL cholesterol is therefore considered the "bad" cholesterol. Last Editorial Review: 6/14/2012
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