Definition of Y-linked inheritance

Y-linked inheritance: Inheritance of genes on the Y chromosome. Since only males normally have a Y chromosome, Y-linked genes can only be transmitted from father to son.

Y-linked inheritance is also called holandric inheritance.

A number of genes were are known to be Y-linked including:

  • ASMTY (which stands for acetylserotonin methyltransferase),
  • TSPY (testis-specific protein),
  • IL3RAY (interleukin-3 receptor),
  • SRY (sex-determining region),
  • TDF (testis determining factor),
  • ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
  • AMGL (amelogenin),
  • CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
  • ANT3Y (adenine nucleotide translocator-3 on the Y),
  • AZF2 (azoospermia factor 2),
  • BPY2 (basic protein on the Y chromosome),
  • AZF1 (azoospermia factor 1),
  • DAZ (deleted in azoospermia),
  • RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
  • RBM2 (RNA binding motif protein 2) and
  • UTY (ubiquitously transcribed TPR gene on Y chromosome).


Last Editorial Review: 10/30/2013

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