Definition of RickettsialpoxRickettsialpox: A mild infectious disease first observed in New York City that is caused by Rickettsia akari and is transmitted from its mouse host by chigger or adult mite bites. Features include fever, a dark spot that becomes a small ulcer at the site of the bite, swollen glands (satellite lymphadenopathy) near the site of the bite, and a raised, blistering (vesicular) rash. Treatment is with antibiotics. Last Editorial Review: 3/19/2012
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