Definition of Pickwickian syndromePickwickian syndrome: The combination of obesity, somnolence (sleepiness), hypoventilation (underbreathing), and plethoric (red) face. The syndrome is so named because of the "fat and red-faced boy in a state of somnolency" that Charles Dickens described in his novel, The Pickwick Papers. (The same boy is thought by some experts possibly to have had the Prader-Willi syndrome). Last Editorial Review: 4/27/2011 5:27:15 PM
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