Definition of Paget disease
Paget disease: A chronic bone disorder that typically results in enlarged, deformed bones due to excessive breakdown and formation of bone tissue that can cause bones to weaken and may result in bone pain, arthritis, deformities or fractures. The disease is named for the great English surgeon and pathologist, Sir James Paget (1814-1899).
Paget's disease is rarely diagnosed in people under 40. Men and women are affected equally. Because Paget's disease may be familial, after age 40, brothers, sisters and children of someone with Paget's disease may wish to have an alkaline phosphatase blood test every 2 or 3 years to screen for Paget's disease.
Many people do not know they have Paget's disease because they have a mild case of the disease with no symptoms. Sometimes, symptoms may be confused with those of arthritis or other disorders. The symptoms of Paget's disease can include:
Paget's disease may be diagnosed using one or more of the following tests:
The outlook with Paget's disease is generally good, particularly if treatment is given before major changes have occurred in the affected bones. Paget's disease occurs most frequently in the spine, skull, pelvis, thighs, and lower legs. In general, symptoms progress slowly, and the disease does not spread to normal bones. Treatment can control Paget's disease and lessen symptoms but is not a cure.
Paget's disease may lead to other medical conditions, including:
Paget's disease is NOT associated specifically with osteoporosis. Although Paget's disease and osteoporosis can occur in one and the same person, they are completely different disorders. But, despite their marked differences, many treatments for Paget's disease can also be used to treat osteoporosis.
The goal of drug treatment is to control Paget's disease activity for as long a period of time as possible. Treatment options include aspirin, other anti-inflammatory medications, pain medications, and medications that slow the rate of bone turnover, such as calcitonin (Calcimar, Miacalcin) and the bisphosphonates including etidronate (Didronel), alendronate (Fosamax), pamidronate (Aredia), tiludronate (Skelid), and risedronate (Actonel).
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