Definition of Osteo- (prefix)Osteo- (prefix): Combining form meaning bone. From the Greek "osteon", bone. Appears for instance in osteoarthritis, osteochondroma osteodystrophy, osteogenesis, osteomyelitis, osteopathy, osteopetrosis, osteoporosis, osteosarcoma, etc. Last Editorial Review: 6/14/2012
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