Definition of Neo- (prefix)Neo- (prefix): Prefix meaning new. From the Greek "neos", new, young, fresh, recent. Examples of terms starting with "neo-" include neonatal and neonate (the newborn), neoplasia and neoplasm (new growth = tumor), etc. The opposite of neo- is paleo-. Although paleo- does enter occasionally into medical usage, it is far less commonly encountered than neo- in medicine (and on the pharmacy shelves where there is Neomycin but no Paleomycin). Last Editorial Review: 6/14/2012
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