Definition of Lower GI seriesLower GI series: Short for lower gastrointestinal series. A series of x-rays of the rectum, colon and lower section of the small intestine taken after the patient has a barium enema. Barium is a white, chalky substance that coats the organs so they will show up on the x-ray. Also called a barium enema or a barium enema x-ray. Last Editorial Review: 4/27/2011 5:27:15 PM
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