Definition of Locus minoris resistentiaeLocus minoris resistentiae: Latin meaning a place of less resistance. A locus minoris resistentiae offers little resistance to microorganisms. For example, a damaged heart valve acts as a locus minoris resistentiae, a place where any bacteria in the bloodstream tend to settle. The concept of a locus minoris resistentiae is an old one but still a valid, useful way of thinking. Last Editorial Review: 6/14/2012
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