Definition of ImmunosuppressionImmunosuppression: Suppression of the immune system and its ability to fight infection. Immunosuppression may result from certain diseases, such as AIDS or lymphoma, or from certain drugs, such as some of those used to treat cancer. Immunosuppression may also be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation, to prevent the rejection of a transplant. Also known as immunodepression. Last Editorial Review: 3/19/2012
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