Definition of Post-thrombotic syndromePost-thrombotic syndrome: The complications that may follow deep vein thrombosis (DVT). The complications after DVT may include persistent edema (swelling), pain, purpura (bleeding into the skin), increased skin pigmentation, eczematoid (eczema-like) dermatitis, pruritus (itchiness), ulceration, and cellulitis (bacterial infection just below the skin). All of these complications result from the impaired return of blood through the veins of the lower leg to the heart. Also called the postphlebitic syndrome. Last Editorial Review: 6/14/2012
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