Definition of HemoglobinuriaHemoglobinuria: The presence of free hemoglobin in the urine, which may make the urine look dark. Normally, there is no hemoglobin in the urine. Hemoglobinuria is a sign of a number of abnormal conditions, such as bleeding and paroxysmal nocturnal hemoglobinuria. Last Editorial Review: 3/19/2012
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