Definition of Fine needle aspirationFine needle aspiration: The use of a thin needle to withdraw material from the body for analysis. For example, when a nodule is felt in the thyroid, fine needle aspiration may be done to remove a tissue sample that can be examined to determine whether the nodule is benign or malignant. The aspirated material is examined under the microscope by a pathologist. Last Editorial Review: 3/19/2012
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