Definition of RANTESRANTES: A cytokine that is a member of the interleukin-8 superfamily of cytokines. RANTES is a protein. It is a selective attractant for memory T lymphocytes and monocytes. It binds to CCR5, a coreceptor of HIV. RANTES is an acronym for Regulated on Activation, Normal T Expressed and Secreted. It is also known as CCL5. Last Editorial Review: 6/14/2012
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