Definition of de Musset signde Musset sign: Rhythmic nodding or bobbing of the head in synchrony with the heart beat, a sign of aortic insufficiency --incompetence of the aortic valve with aortic regurgitation. The causes include syphilitic aortitis, rheumatic fever, and aortic aneurysm. Named after the French Romantic poet and playwright Alfred de Musset (1810-1857). Last Editorial Review: 6/14/2012
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