Definition of SemenSemen: The fluid that is released through the penis during orgasm. Semen is made up of fluid and sperm. The fluid comes from the prostate, seminal vesicles, and other sex glands. The sperm are manufactured in the testicles. The seminal fluid helps transport the sperm during orgasm. Seminal fluid contains sugar as an energy source for sperm. Last Editorial Review: 3/19/2012
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