Definition of Clot-dissolving medicationClot-dissolving medication: An agent such as plasminogen-activator (t-PA) or streptokinase that is effective in dissolving clots and reopening arteries. For example, clot-dissolving medications may be used in the treatment of heart attacks, to reestablish blood flow to the heart muscle (myocardium). Also known as thrombolytic agents. Last Editorial Review: 3/19/2012
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