Definition of Frailty syndromeFrailty syndrome: A condition, seen particularly in older patients, characterized by low functional reserve, easy tiring, decrease of libido, mood disturbance, accelerated osteoporosis, decreased muscle strength, and high susceptibility to disease. People with the frailty syndrome may take a sudden turn for the worse and die. However, the frailty syndrome may sometimes be reversible. Last Editorial Review: 6/14/2012
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