Definition of Cancer, oralCancer, oral: A malignant tumor of the mouth area. A sore in the mouth that does not heal can be a warning sign of oral cancer. A biopsy is the only way to determine whether an abnormal area in the oral cavity is cancerous. Oral cancer is almost always caused by tobacco (smoking and chewing) or alcohol use. Surgery to remove the tumor in the mouth is the usual treatment. Last Editorial Review: 3/19/2012
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