Definition of Epidermolysis bullosaEpidermolysis bullosa: One in a group of blistering skin conditions. The skin is so fragile in people with epidermolysis bullosa that even minor rubbing may cause blistering. The four major types of epidermolysis bullosa are EB simplex, junctional epidermolysis bullosa, dystrophic epidermolysis bullosa, and Kindler syndrome. Last Editorial Review: 10/2/2012
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