Definition of Arthritis, degenerativeArthritis, degenerative: A type of arthritis caused by inflammation, breakdown, and eventual loss of the cartilage of the joints. Degenerative arthritis is the most common form of arthritis, usually affecting the hands, feet, spine, and large weight-bearing joints, such as the hips and knees. Also known as osteoarthritis and degenerative joint disease. Last Editorial Review: 3/19/2012
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