Definition of Lamin A

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Lamin A: Abbreviated LMNA. A gene on chromosome 1 that encodes a protein which is a key component of the membrane surrounding the cell nucleus.

Mutations in the LMNA gene are responsible for a number of genetic disorders including:

• Progeria syndrome,
• Emery-Dreifuss muscular dystrophy type 2,
• Limb girdle muscular dystrophy type 1B,
• Charcot-Marie-Tooth disorder type 2B1,
• The Dunnigan type of familial partial lipodystrophy,
• Mandibuloacral dysplasia and
• A familial form of dilated cardiomyopathy.

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