Definition of Oculodentodigital dysplasiaOculodentodigital dysplasia: A genetic disorder that affects many body structures and systems, including the eyes, face, teeth, fingers and toes, and may also cause hearing loss, heart trouble and neurological problems. The disorder is due to mutation (change) in a gene called connexin 43. Also called the ODD syndrome. Last Editorial Review: 6/14/2012
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