Definition of Prophase chromosomeProphase chromosome: A chromosome at the prophase stage in the cell cycle, before metaphase (when a chromosome is most highly condensed). The chromosomes in prophase are distended and often tangled like a ball of twine within the nucleus of the cell. However, when fine chromosomal details are important, prophase chromosomes are frequently selected for high resolution chromosome banding and analysis. Last Editorial Review: 6/14/2012
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