Definition of HEPAHEPA: Acronym that stands for High-Efficiency Particulate Air and for High-Efficiency Particulate Arrestor. HEPA filters are used for isolation and immunocompromise units, operating rooms, removal of allergens from the air (for hay fever, asthma, etc.) and other applications where maximum reduction or removal of submicron particulate matter from air is required. Last Editorial Review: 6/14/2012
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