Definition of Myo- (prefix)Myo- (prefix): A prefix denoting a relationship to muscle. Myo- enters into many words and terms in medicine including cardiomyopathy, dermatomyositis, electromyography, leiomyoma, myocardial infarction, myocarditis, myocardium, myoclonic, myocyte, myopathy, myoglobin, myometrium, myotonia, myotonic dystrophy, and polymyositis. Last Editorial Review: 6/14/2012
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