Definition of Cemento-ossifying fibromaCemento-ossifying fibroma: A hard fibrous growth that continues to enlarge, sometimes to very significant size, unless treated, most frequently seen in the jaw or mouth, sometimes in connection with a fracture or another type of injury. Treatment is by surgery. After excision of the primary tumor, local recurrence develops in 25% to 44% of patients, and is often associated with inadequate surgical margins. Last Editorial Review: 6/14/2012
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