Definition of VesiclesVesicles: In dermatology, vesicles are small blisters, most often on the skin. Vesicles also can crop up on the mucous membranes, such as the buccal mucosa (the lining of the mouth). In anatomy, a vesicle is any small pouch. The word vesicle comes from the Latin diminutive vesiculum meaning a small bag or bladder. Last Editorial Review: 6/14/2012
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