Definition of PapulesPapules: Small solid rounded bumps rising from the skin that are each usually less than 1 centimeter in diameter (less than 3/8 inch across). The term "papule" is derived from Latin from "papula," a pimple. Dermatologists call any small solid circumscribed bump in the skin a papule, as opposed to a vesicle which contains fluid or a macule which is flat and even with the surrounding skin. Last Editorial Review: 9/20/2012
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