Definition of HepatoblastomaHepatoblastoma: A malignant tumor of the liver. Hepatoblastoma occurs almost exclusively in young children, more commonly in boys than in girls. The diagnosis of hepatoblastoma is usually made after abdominal swelling (from liver enlargement caused by the tumor) is noticed. Although small tumors can sometimes be treated successfully with surgery, the prognosis with hepatoblastoma is generally poor. Last Editorial Review: 6/14/2012
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