Definition of ArachnophobiaArachnophobia: An abnormal and persistent fear of spiders. Sufferers from arachnophobia experience undue anxiety, even though they realize that the risk of encountering a spider and being harmed by it is small or nonexistent. They may avoid going barefoot and may be especially alert when taking showers or getting into and out of bed. Last Editorial Review: 3/19/2012
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