Definition of Histiocytosis, malignantHistiocytosis, malignant: A term sometimes used to refer to a group of tumors including monocyte-related leukemias (for example, acute monocytic leukemia, acute myelomonocytic leukemia), extramedullary monocytic tumor, and histiocytic sarcoma. Treatment is by radiation and chemotherapy, and in some cases bone-marrow transplantation. See also histiocytosis. Last Editorial Review: 10/3/2012
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