Definition of Headache, sinusHeadache, sinus: A headache caused by pressure within the sinus cavities of the head, usually in connection with sinus infection. The sufferer has pain and tenderness in the sinus area, discharge from the nose, and sometimes a swollen face. Treatment involves treating the underlying condition, which is often an allergy, and using nasal vasoconstrictors and analgesic medications. Last Editorial Review: 3/19/2012
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