Definition of Syphilis, tertiarySyphilis, tertiary: The third stage of syphilis, in which the syphilis spirochetes infect the brain, heart, and other organs of the body. Dementia is a common outcome. Tertiary syphilis can develop many years after an initial untreated infection. The spirochetes can cause extensive damage in the body, sometimes leading to death. Last Editorial Review: 9/20/2012
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