Definition of Sturge-Weber syndromeSturge-Weber syndrome: A congenital, but not inherited, disorder that affects the skin, the neurological system, and sometimes the eyes and internal organs. The main sign of Sturge-Weber syndrome is a port wine stain birthmark. Neurological symptoms may include seizures and developmental delay. Also known as encephelotrigeminal angiomatosi. See also port wine stain. Last Editorial Review: 4/27/2011 5:27:15 PM
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