Definition of Staphylococcus, antibiotic-resistantStaphylococcus, antibiotic-resistant: A form of staphylococcus bacteria that is unaffected by certain antibiotics. Antibiotic-resistant staphylococcus is a growing problem, particularly in hospitals, where staph infections can run rampant. Treatment involves using 'super-antibiotics' when possible, although this type of infection can prove to be untreatable and deadly. Last Editorial Review: 3/19/2012
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