Definition of CastCast: 1) A protective shell of fiberglass, plastic, or plaster, and bandage that is molded to protect broken or fractured limb(s) as it heals. 2) An abnormal mass of dead cells that forms in a body cavity. For example, cases of cells that form in the tubules of the kidneys are sometimes detected in urine samples. Last Editorial Review: 4/27/2011 5:27:15 PM
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