Definition of CSF (colony-stimulating factor)CSF (colony-stimulating factor): A laboratory-made agent similar to a substance in the body that stimulates the production of blood cells. The colony-stimulating factors (CSFs) include granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Treatment with colony-stimulating factors can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy. Last Editorial Review: 6/14/2012
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