Definition of NonoxynolNonoxynol: Nonoxynol-9 is the most commonly encountered spermatocide in the United States. As with other spermatocides, it destroys spermatozoa; it kills sperm. The nonoxynols, technically speaking, are nonionic surfactant [surface active] mixtures that vary in the number of repeating ethoxy groups. They are much used as detergents, emulsifiers, wetting and defoaming agents, etc. Nonoxynol-9 has 9 repeating ethoxy groups. It is the active component of most vaginal foams and creams. Last Editorial Review: 6/14/2012
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